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First demonstration of recombination between the gene for Norrie disease and probe L1.28
S Katayama1, M Wohlferd, M S Golbus
1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
American Journal of Medical Genetics
|August 1, 1988
Abstract:
Norrie disease is an X-linked trait thought to be tightly linked to the anonymous probe L1.28. Here we report the first recombinational event among 24 informative meioses. This indicates there is a 4% (95% C.L. 0.1%-21%) error rate introduced by meiotic crossovers in carrier or prenatal diagnosis based on linkage between Norrie disease and L1.28.