Bring Back the Rat!

The authors conducted a comprehensive literature review to synthesize historical and contemporary evidence. Their review approach involved evaluating published studies from the 1970s to the present day. They systematically compared physiological and behavioral data between two common rodent species. This analysis focused on identifying unique strengths of each model within gerontology. The team examined trends in publication frequency to document the shift in research preferences. They synthesized findings across four distinct biological categories to provide a balanced perspective. No experimental procedures were performed, as this was a purely theoretical assessment of existing knowledge. The researchers aimed to highlight overlooked advantages of the rat model for modern investigators.

The authors report that the use of rats in aging studies peaked in 1992 before declining significantly by 2018. Key findings from the literature indicate that rats offer distinct advantages in longevity interventions compared to mice. The review highlights that rats provide unique insights into pathology and physiology that are often missed in mouse-only studies. Behavioral and cognitive testing in rats remains a robust tool for understanding age-related decline. The researchers demonstrate that historical contributions of the rat model are largely underappreciated by current investigators. They show that species-specific differences in phylogeny and domestication impact the validity of aging models. The data suggest that the mouse has become the preeminent model despite the proven utility of the rat. These results indicate that a broader range of mammalian models is required to advance the field.

The authors propose that reintroducing rats could significantly enhance our grasp of complex aging processes. Their synthesis suggests that rats provide distinct physiological insights that mice may lack. Researchers argue that relying solely on one species limits the breadth of biological discovery. They emphasize that historical data from rats remains highly relevant to contemporary investigations. The review implies that species-specific differences are not merely obstacles but opportunities for deeper understanding. Scientists should consider the unique behavioral and cognitive traits of rats when designing future experiments. This work advocates for a more diverse approach to selecting animal models in gerontology. Ultimately, the authors suggest that a dual-model strategy is superior for advancing the field.