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Bridging the gap between hypertrabeculation phenotype, noncompaction phenotype and left ventricular noncompaction

Vittoria Vergani1, Davide Lazzeroni2, Giovanni Peretto3

  • 1Department of Clinical Cardiology, IRCCS San Raffaele Hospital and University.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|January 3, 2020
PubMed

Insights

Left ventricular noncompaction (LVNC) is a heart condition with excessive trabeculation. This review offers a diagnostic algorithm to differentiate LVNC from benign hypertrabeculation, aiding clinical decision-making.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Medical Diagnostics

Background:

  • Left ventricular noncompaction (LVNC) is a cardiomyopathy defined by excessive cardiac trabeculation and deep recesses.
  • While hypertrabeculation is linked to heart failure and arrhythmias, it alone does not confirm LVNC.
  • Current diagnostic tools are insufficient to distinguish between asymptomatic hypertrabeculation and actual LVNC.

Purpose of the Study:

  • To review existing literature on diagnostic criteria for LVNC.
  • To develop a practical diagnostic algorithm for differentiating LVNC phenotypes.
  • To aid clinicians in distinguishing between hypertrabeculation, non-compaction phenotype, and LVNC cardiomyopathy.

Main Methods:

  • Comprehensive literature review of studies on LVNC diagnostic criteria.
  • Analysis of parameters used to predict adverse cardiovascular events in LVNC.
  • Development of a simplified diagnostic algorithm based on reviewed criteria.

Main Results:

  • Hypertrabeculation alone is not a definitive diagnostic marker for LVNC.
  • Existing literature lacks clear consensus on differentiating LVNC from hypertrabeculation.
  • An accessible algorithm is proposed to aid in clinical differentiation.

Conclusions:

  • A clear distinction between hypertrabeculation and LVNC is crucial for accurate diagnosis and risk stratification.
  • The proposed algorithm aims to provide physicians with an effective tool for LVNC diagnosis.
  • Further validation of the diagnostic algorithm is warranted to improve patient outcomes.

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