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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
Pathway Complexity in Fuel-Driven DNA Nanostructures with Autonomous Reconfiguration of Multiple Dynamic Steady
Jie Deng1,2,3,4, Andreas Walther1,2,3,4
1A3BMS Lab, Institute for Macromolecular Chemistry , University of Freiburg , Stefan-Meier-Straße 31 , 79104 Freiburg , Germany.
None:
We introduce pathway complexity on a multicomponent systems level in chemically fueled transient DNA polymerization systems, achieving autonomous evolution over multiple structural dynamic steady states from monomers to dimers, oligomers of dimers, and randomized polymer structures before being ultimately degraded back to monomers once the fuel is consumed. The enabling key principle is to design monomer species having kinetically selected molecular recognition in the structure-forming step and which are reconfigured in an enzymatic reaction network. This nonequilibrium systems chemistry approach to pathway complexity provides new conceptual insights into fuel-driven automatons and autonomous materials design.
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