Adjunctive therapy with brexpiprazole improves treatment resistant complex post traumatic stress disorder in domestic family violence victims
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Updated: Dec 31, 2025

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Published on: January 18, 2021
1Department of Psychiatry, The University of Melbourne, Australia.
Objective:
Domestic family violence (FV) is a serious problem with serious impacts on mental health of victims. One such impact is post-traumatic stress disorder (PTSD), and it can be resistant to treatment (treatment-resistant or TR). This article offers novel treatment.
Methods:
Two treatment resistant case studies are described where adjunctive treatment with brexpiprazole was commenced. Possible theoretical considerations are presented to explain improvement.
Results:
Adjunctive treatment with brexpiprazole was associated with significant improvement in FV subjective and objective measures, with enhanced response to trauma therapy.
Conclusion:
Brexpiprazole improved complex post traumatic stress disorder in FV victims and needs further evaluation.
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