Corticomotor function is associated with quadriceps rate of torque development in individuals with ACL surgery

Impaired corticomotor function arising from altered intracortical and corticospinal pathways are theorized to impede muscle recovery following anterior cruciate ligament (ACL) surgery, yet functional implications of centrally driven adaptations remain unclear. We aimed to assess relationships between quadriceps corticomotor and neuromechanical function after ACL surgery, and to compare with contralateral and control limbs. 16 individuals after primary, unilateral ACL surgery and 16 sex- and age-matched controls participated. Corticomotor function was assessed using transcranial magnetic stimulation, and quantified via active motor thresholds (AMT), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF). Neuromechanical function was quantified via electromechanical delay, early and late-phase rate of torque development (RTD_0-50, RTD_100-200), coefficient of variation, maximal voluntary isometric contraction (MVIC) torque, and central activation ratio. We observed significant correlations in the ACL limbs between: AMT and RTD_0-50 (r = - 0.513, p = 0.031), SICI and RTD_100-200 (r = 0.501, p = 0.048), AMT and SICI (r = - 0.659, p = 0.010), AMT and ICF (r = 0.579, p = 0.031), RTD_0-50 and MVIC (r = 0.504, p = 0.023), and RTD_100-200 and MVIC (r = 0.680, p = 0.002). The ACL limbs demonstrated higher AMT compared to controls (44.9 ± 8.4 vs. 30.1 ± 8.2%, p < 0.001), and lesser MVIC torque (2.37 ± 0.52 vs. 2.80 ± 0.59 Nm/kg, p = 0.005) and RTD_100-200 (6.79 ± 1.72 vs. 7.90 ± 1.98 Nm/kg/s, p = 0.006) compared to the contralateral limbs. Our findings indicate that lesser corticospinal excitability is associated with lesser early-phase RTD, and greater intracortical inhibition is associated with lesser late-phase RTD. These findings provide evidence of implications of altered intracortical and corticospinal pathways relative to the ability to rapidly generate quadriceps torque following ACL surgery.