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A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery
E A Katsareli1, C Amerikanou1, K Rouskas2
1Harokopio University of Athens, Department of Nutrition and Dietetics, Athens, Greece.
Obesity Surgery
|January 4, 2020
Summary
A genetic risk score (GRS) may predict weight loss after bariatric surgery. Higher GRS was associated with less excess weight loss at 12 and 24 months post-surgery in obese patients.
Area of Science:
- Bariatric Surgery
- Genetics
- Obesity Research
Background:
- Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are leading bariatric procedures.
- Obesity is a global health concern requiring effective surgical interventions.
- Predicting surgical outcomes is crucial for patient management.
Purpose of the Study:
- To investigate the association between a genetic risk score (GRS) and excess weight loss (%EWL) after bariatric surgery.
- To determine if genetic predisposition influences weight loss outcomes in patients undergoing SG or RYGB.
- To explore the utility of GRS as a predictive tool for bariatric surgery success.
Main Methods:
- Prospective study of 47 morbidly obese Greek patients undergoing SG or RYGB.
- Weight loss assessed as %EWL at 12 and 24 months post-surgery.
- GRS constructed from BMI- and WHR-related SNPs; analyzed using multiple linear regression models.
Main Results:
- GRS significantly associated with %EWL at 12 months, with a 4.618% decrease per score unit.
- GRS also significantly associated with %EWL at 24 months, showing a ~3% decrease per score unit.
- Positive correlation between %EWL at 12 and 24 months suggests sustained weight loss trends.
Conclusions:
- GRS demonstrates predictive value for weight loss outcomes following bariatric surgery.
- GRS can potentially be integrated with other preoperative factors to personalize surgical outcome predictions.
- Further research may refine GRS for enhanced patient selection and post-operative management strategies.
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