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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2018 Annual Data Report: Lung.

M Valapour1,2, C J Lehr2, M A Skeans1

  • 1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 4, 2020
PubMed
Summary
This summary is machine-generated.

US lung transplant policy prioritizes high-mortality risk candidates. Despite increased transplants and donors in 2018, many adult and child candidates still died or worsened while awaiting lung transplantation.

Keywords:
LASEnd-stage lung diseaselung allocation scorelung transplantorgan allocationrevised lung allocation scoretransplant outcomes

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Area of Science:

  • Medicine
  • Transplantation
  • Public Health Policy

Background:

  • The US lung allocation policy aims to prioritize candidates with the highest risk of mortality for lung transplantation.
  • Lung transplantation numbers have risen significantly, with 2562 procedures in 2018, a 31% increase over five years.
  • Despite increased organ availability and transplants, a substantial number of candidates remain on the waiting list.

Purpose of the Study:

  • To analyze the outcomes of lung transplantation in 2018, focusing on candidate access and mortality.
  • To examine the trends in lung transplant waiting lists, including adult and pediatric populations.
  • To evaluate the effectiveness of current lung allocation policies in addressing candidate needs.

Main Methods:

  • Analysis of national lung transplant data from 2018.
  • Review of candidate waiting list statistics, including additions, removals, and reasons for removal.
  • Examination of transplant numbers by recipient age group, particularly for pediatric recipients (0-11 years).

Main Results:

  • In 2018, 2562 lung transplants were performed, with a notable increase in procedures and donor availability.
  • Despite increased transplants, 365 adult candidates died or became too ill for transplant.
  • Fifteen lung transplants were performed in children aged 0-11 years; 59.3% of child candidates were removed from the waiting list due to undergoing transplant, while 22.2% died.

Conclusions:

  • While lung transplant activity has increased, critical challenges remain in timely access for high-risk candidates.
  • The data highlights the ongoing need to balance organ allocation with patient mortality risk.
  • Further evaluation of lung allocation policies is warranted to improve outcomes for all candidates, especially pediatric populations.