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Therapeutic Approach of Probiotics in Children with Atopic Dermatitis
1Department of Pharmacology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun-248001, India.
Insights
Pediatric atopic dermatitis (AD) is a common skin condition. Gut bacteria imbalance may cause AD, and probiotics show potential for treatment, though more research is needed for consistent results.
Area of Science:
- Dermatology
- Microbiology
- Pediatrics
Background:
- Pediatric atopic dermatitis (AD) is a prevalent, chronic inflammatory skin condition affecting 20% of children globally.
- Increasing prevalence and significant socioeconomic burden highlight the need for effective treatments.
- Current AD treatments have potential side effects, necessitating alternative therapeutic strategies.
Purpose of the Study:
- To review the link between gut dysbiosis and pediatric atopic dermatitis.
- To summarize clinical evidence on probiotic use for AD prevention and treatment in children.
Main Methods:
- Literature review of studies investigating gut microbiota and probiotics in pediatric AD.
- Analysis of clinical trial data on the efficacy of probiotics for AD management.
Main Results:
- Emerging evidence suggests gut microflora imbalance (dysbiosis) contributes to AD development.
- Probiotic administration shows promise in managing pediatric AD, but results are inconsistent.
- Further research is required to establish conclusive evidence and optimal probiotic strategies.
Conclusions:
- Gut dysbiosis is a potential contributing factor to pediatric atopic dermatitis.
- Probiotics represent a promising avenue for AD management, warranting further investigation.
- Consistent and conclusive evidence is needed to fully establish the role of probiotics in pediatric AD.
Abstract:
Pediatric atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease, affecting 20% of children all over the world especially in developed countries. The global prevalence of AD in children has been increasing over recent years. This chronic inflammatory skin disease causes economic and social burden to the family. The exact cause of AD is not known, however recent studies suggest that the imbalance of microflora present in the gut leads to AD. The current treatment of AD involves the application of moisturizer, topical corticosteroids, antihistamines and antibiotics. This line of treatment of AD in children has many side effects. An alternative novel therapeutic approach has to be explored to combat this chronic skin disease. In recent years, there has been increasing interest in the use of probiotics in the modulation of gut microbiota for the management of AD. Many research studies showed that the administration of probiotics gives positive results in the prevention and treatment of AD in children, however, the results are not consistent and conclusive. In this review, the phenomenon that the dysbiosis of the gut flora contributes to the development of AD is addressed and clinical evidence of probiotics in the prevention and treatment of AD children is also summarised.
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