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Post-menopausal Osteoporosis and Probiotics
Sangeeta Huidrom1, Mirza Atif Beg1, Tariq Masood2
1Department of Pharmacology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun - 248001, Uttarakhand, India.
Current Drug Targets
|October 28, 2020
Summary
Probiotics may offer a safe and effective alternative for treating postmenopausal osteoporosis (PMO). This review explores how gut bacteria influence bone health and summarizes probiotic benefits in PMO models and women.
Area of Science:
- Bone Biology and Metabolism
- Microbiome Research
- Women's Health
Background:
- Postmenopausal osteoporosis (PMO) involves bone loss due to estrogen deficiency, increasing fracture risk.
- Current PMO treatments have side effects, including potential tumorigenesis, necessitating safer alternatives.
- Emerging evidence links intestinal microbiota to bone health.
Purpose of the Study:
- To review bone remodeling processes.
- To elucidate the role of intestinal microbiota in bone metabolism.
- To summarize current research on probiotics for PMO.
Main Methods:
- Literature review of bone remodeling.
- Analysis of studies on gut microbiota and bone health.
- Synthesis of research on probiotic interventions in PMO.
Main Results:
- Estrogen deficiency disrupts bone remodeling, favoring resorption over formation.
- Intestinal microbiota composition influences host bone metabolism.
- Probiotic interventions show promise in animal models and human studies of PMO.
Conclusions:
- Probiotics represent a potential therapeutic strategy for postmenopausal osteoporosis.
- Modulating the gut microbiota could be a novel approach to bone health management.
- Further research is warranted to optimize probiotic use for PMO.
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