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Related Concept Videos

Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Spongy Bone01:09

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Updated: Dec 31, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Primary bone sarcoma with BCOR internal tandem duplication.

Faizan Malik1, Riyam T Zreik2, Dale J Hedges3

  • 1Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Virchows Archiv : an International Journal of Pathology
|January 5, 2020
PubMed
Summary
This summary is machine-generated.

BCOR internal tandem duplications (ITDs) are now identified in bone sarcomas, previously only seen in soft tissues. This finding expands the spectrum of BCOR ITD sarcomas and impacts treatment strategies.

Keywords:
BCOR internal tandem duplicationEwing-like sarcomaPrimitive sarcoma

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • BCOR internal tandem duplications (ITDs) and rearrangements are key drivers in specific undifferentiated sarcomas.
  • BCOR ITD sarcomas were historically confined to infantile soft tissues, while BCOR rearrangements appeared in bone and soft tissues across a broader age range.

Observation:

  • A case of a BCOR-expressing undifferentiated sarcoma in an adolescent male's tibia was unexpectedly found to have a BCOR ITD, not a rearrangement.
  • This patient showed a partial histologic response to Ewing sarcoma chemotherapy.

Findings:

  • The study expands the known clinical spectrum of BCOR ITD sarcomas to include primary bone tumors in adolescents.
  • The findings suggest BCOR ITD should be screened for in both pediatric and adult BCOR-expressing undifferentiated sarcomas, regardless of tissue type.

Implications:

  • Accurate identification of BCOR mutations (ITDs and rearrangements) is crucial for defining the clinical spectrum of undifferentiated sarcomas.
  • This genetic screening is essential for developing targeted and effective management strategies for these rare tumors.