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Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Related Experiment Video

Updated: Dec 31, 2025

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Multimodal imaging characterization of peripheral drusen.

Eleonora Corbelli1, Enrico Borrelli1, Mariacristina Parravano2

  • 1Department of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 5, 2020
PubMed
Summary

Peripheral drusen, imaged using multimodal techniques, show distinct features. These findings suggest peripheral drusen may represent a separate condition from age-related macular degeneration (AMD).

Keywords:
Age-related macular degenerationDrusenMultimodal imagingPeripheral retinaUltra-widefield

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Peripheral drusen are often observed in eyes, but their relationship with age-related macular degeneration (AMD) is not fully understood.
  • Multimodal imaging offers a comprehensive approach to characterizing retinal lesions.

Purpose of the Study:

  • To characterize peripheral drusen using integrated multimodal imaging.
  • To analyze the association between peripheral drusen and macular findings in age-related macular degeneration (AMD).

Main Methods:

  • Retrospective, cross-sectional study involving 57 eyes with peripheral drusen.
  • Utilized Optos and Spectralis devices for ultra-widefield (UWF) pseudocolor, fundus autofluorescence (FAF), and spectral domain optical coherence tomography (SD-OCT) imaging.
  • Independent grading of images for peripheral drusen presence, features, and topographical distribution.

Main Results:

  • Peripheral drusen were identified in all eyes, with high concordance between graders on pseudocolor images.
  • SD-OCT revealed a high reflective core in 97.1% of peripheral drusen.
  • Macular involvement consistent with early/intermediate AMD was present in 43.5% of eyes, and late AMD in 10.5%.

Conclusions:

  • Multimodal imaging provides a detailed assessment of peripheral drusen.
  • Peripheral drusen exhibit unique characteristics that differentiate them from AMD.
  • These findings suggest peripheral drusen may be a distinct entity rather than a manifestation of AMD expansion.