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Role of SNHG16 in human cancer

Chao-Yang Gong1, Rong Tang2, Wei Nan2

  • 1The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 6, 2020
PubMed

Insights

Small nucleolar RNA host gene 16 (SNHG16), a long non-coding RNA (lncRNA), acts as an oncogene in various cancers. This review details SNHG16

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators in physiological and pathological processes, including cancer.
  • Many lncRNAs function as oncogenes or tumor suppressors, influencing cancer development.
  • Small nucleolar RNA host gene 16 (SNHG16) is recognized as an oncogenic lncRNA in neuroblastoma and other malignancies.

Purpose of the Study:

  • To review the biological functions of SNHG16 in human cancers.
  • To elucidate the underlying mechanisms by which SNHG16 regulates cancer progression.
  • To discuss the potential clinical significance of SNHG16 as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of studies investigating SNHG16 in various cancers.
  • Analysis of experimental data on SNHG16's role in cell proliferation, apoptosis, invasion, and metastasis.
  • Synthesis of information on SNHG16's association with clinical and pathological characteristics.

Main Results:

  • SNHG16 overexpression is linked to adverse clinical and pathological features in cancer patients.
  • SNHG16 regulates key cancer cell behaviors, including proliferation, apoptosis, invasion, and metastasis.
  • Diverse molecular mechanisms mediate SNHG16's oncogenic functions.

Conclusions:

  • SNHG16 plays a significant role in the development and progression of multiple human cancers.
  • SNHG16 exhibits potential as a promising diagnostic biomarker for cancer.
  • Targeting SNHG16 may offer a novel therapeutic strategy for cancer treatment.
Keywords:
BiomarkerCancersSNHG16lncRNA

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