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Cutaneous alternariosis.

T Iwatsu1

  • 1Iwatsu Dermatological Clinic, Chiba, Japan.

Archives of Dermatology
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

A rare fungal infection caused by Alternaria tenuissima presented as a cheek lesion. Intralesional amphotericin B effectively treated the granulomatous inflammation.

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Cutaneous fungal infections can present with varied clinical manifestations.
  • Granulomatous inflammation is a common host response to certain fungal pathogens.

Observation:

  • A 77-year-old female presented with a five-year history of a slowly progressing, infiltrated, dark-red plaque on her left cheek.
  • Dermal biopsy revealed mixed-cell granulomatous infiltration with observable hyphae.

Findings:

  • Alternaria tenuissima was identified as the causative fungal agent.
  • Antimycotic susceptibility testing indicated sensitivity to amphotericin B and ketoconazole.
  • The patient's lesion was successfully treated with intralesional amphotericin B injections.

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Implications:

  • This case highlights Alternaria tenuissima as a potential cause of chronic cutaneous granulomatous lesions.
  • Intralesional amphotericin B can be an effective treatment option for localized Alternaria fungal infections.
  • Early diagnosis and targeted antifungal therapy are crucial for managing such rare dermatological conditions.