Related Experiment Video
Updated: Dec 31, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Small molecular interaction-based fluorescence enhancement for second near-infrared imaging
Wang Zian1, Liu Yang1, Wang Peng2,3
1School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, PR China.
Abstract:
Aim: This study described a new strategy to enhance second near-infrared (NIR-II) fluorescence intensity. Materials & methods: NIR-II liposomes were prepared by thin film hydration method and their fluorescence properties were evaluated. The efficacy of the optimized liposome was then evaluated in vivo with low dose and irradiation. Results: Indocyanine green-IR1061 liposome exhibited higher fluorescence intensity (∼fourfold than IR1061 liposome) with the red-shifted emission. The intensity of indocyanine green-IR1061 cationic liposome was enhanced to approximately tenfold, which allowed us to perform angiography with lower doses and less exposure time. Conclusion: We report a new and efficient way to enhance NIR-II fluorescence intensity. This could be used to acquire high temporal resolution and signal-to-background ratio fluorescence imaging.
Related Concept Videos
Super-resolution Fluorescence Microscopy
Total Internal Reflection Fluorescence Microscopy

