CTRP12 in cardiovascular and metabolic diseases: current status and future perspective

Area of Science:

• Endocrinology
• Cardiovascular Science
• Metabolic Disease Research

Background:

• Cardiovascular and metabolic diseases pose significant global health challenges.
• C1q tumor necrosis factor-related protein 12 (CTRP12), an adipokine paralogous to adiponectin, is primarily expressed in adipose tissue.
• CTRP12 exists as a full-length protein and a major circulating globular isoform produced by furin cleavage.

Purpose of the Study:

• To comprehensively review the structural characteristics and biological functions of CTRP12.
• To elucidate the association between CTRP12 and major cardiovascular and metabolic diseases.
• To highlight the therapeutic potential of targeting CTRP12.

Main Methods:

• Literature review focusing on CTRP12 structure, function, and disease association.
• Analysis of studies investigating CTRP12's role in inflammation, glucose metabolism, lipid metabolism, oxidative stress, and apoptosis.
• Synthesis of evidence linking CTRP12 dysregulation to specific cardiovascular and metabolic conditions.

Main Results:

• CTRP12 exhibits anti-inflammatory and glucose-lowering properties.
• CTRP12 plays a role in regulating lipid metabolism, oxidative stress, and cellular apoptosis.
• Dysregulation of CTRP12 is implicated in the pathogenesis of coronary artery disease, heart failure, diabetes, obesity, and non-alcoholic fatty liver disease.

Conclusions:

• CTRP12 is a crucial factor in maintaining cardiovascular and metabolic homeostasis.
• Altered CTRP12 levels or function are associated with the development of various metabolic and cardiovascular diseases.
• Targeting CTRP12 presents a promising strategy for the prevention and treatment of these prevalent diseases.