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Bidentate Directing Groups: An Efficient Tool in C-H Bond Functionalization Chemistry for the Expedient Construction
Supriya Rej1, Yusuke Ano1, Naoto Chatani1
1Department of Applied Chemistry, Faculty of Engineering , Osaka University , Suita , Osaka 560-0871 , Japan.
Abstract:
During the past decades, synthetic organic chemistry discovered that directing group assisted C-H activation is a key tool for the expedient and siteselective construction of C-C bonds. Among the various directing group strategies, bidentate directing groups are now recognized as one of the most efficient devices for the selective functionalization of certain positions due to fact that its metal center permits fine, tunable, and reversible coordination. The family of bidentate directing groups permit various types of assistance to be achieved, such as N,N-dentate, N,O-dentate, and N,S-dentate auxiliaries, which are categorized based on the coordination site. In this review, we broadly discuss various C-H bond functionalization reactions for the formation of C-C bonds with the aid of bidentate directing groups.
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