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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
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Polysaccharide-based recoverable double-network hydrogel with high strength and self-healing properties
Kun Lei1, Zhao Li2, Dandan Zhu1
1School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. xlwang@sjtu.edu.cn.
Journal of Materials Chemistry. B
|January 7, 2020
Summary
Researchers developed a novel polysaccharide-based hydrogel (PSBH) with enhanced mechanical and recovery properties. This innovative material combines oxidized sodium alginate and agarose for superior performance in bio-applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Polymer Chemistry
Background:
- Polysaccharide-based hydrogels (PSBHs) are valued for biocompatibility and non-immunogenicity in bio-applications.
- Enhancing the mechanical properties of PSBHs through simple methods remains a significant research challenge.
Purpose of the Study:
- To construct a novel PSBH with superior mechanical and recoverable properties.
- To explore the synergistic and complementary interactions between oxidized sodium alginate and agarose networks.
Main Methods:
- Integration of covalent bond-associated oxidized sodium alginate (SA-CHO) gel and hydrogen bond-associated agarose (Aga) gel.
- Characterization of the mechanical properties, fatigue resistance, shapeability, acid resistance, and self-healing abilities of the composite hydrogel.
Main Results:
- The composite hydrogel demonstrated significantly enhanced compressive stress (17 times) and modulus (15 times) compared to individual gels.
- The hydrogel exhibited excellent fatigue resistance, shape recovery, acid resistance, and self-healing capabilities.
- Synergistic interactions between SA-CHO and Aga networks were key to improved properties.
Conclusions:
- A novel, mechanically robust, and recoverable PSBH was successfully constructed.
- The combination of different polysaccharide networks offers a viable strategy for enhancing hydrogel performance.
- This approach provides a unique perspective for advancing PSBH functionality in various bio-applications.

