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Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting-state and

Xin Di1,2, Heming Zhang1, Bharat B Biswal1,2

  • 1School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Human Brain Mapping
|January 7, 2020
PubMed
Summary

The anterior cingulate cortex (ACC) modulates frontoparietal connectivity differently during resting-state versus working memory tasks. This finding highlights the ACC's role in task-dependent executive functions.

Keywords:
anterior cingulate cortexhigher-order brain connectivitymodulatory interactionphysiophysiological interactionworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • Frontoparietal regions are crucial for working memory and executive functions.
  • Functional connectivity within these regions is modulated by working memory load and external brain regions during rest.
  • The impact of task demands on these modulations remains largely unexplored.

Purpose of the Study:

  • To investigate how task demands influence modulatory interactions between a third brain region and frontoparietal networks during working memory tasks.
  • To compare these modulations during resting-state and different working memory loads (1-back and 2-back).

Main Methods:

  • Functional magnetic resonance imaging (fMRI) data were collected from subjects during resting-state and n-back tasks.
  • Physiological interaction (PPI) analysis was employed using seed regions in the middle frontal gyrus (MFG) and superior parietal lobule (SPL).
  • Task-based functional connectivity was examined across resting-state, 1-back, and 2-back conditions.

Main Results:

  • No consistent modulatory interactions were found across all three conditions for the seed pairs.
  • The anterior cingulate cortex (ACC) exhibited distinct modulatory interactions with the right MFG and SPL across conditions.
  • ACC activity correlated with decreased frontoparietal coupling in resting-state but increased coupling in the 2-back condition.

Conclusions:

  • The anterior cingulate cortex (ACC) plays a significant role in modulating frontoparietal connectivity.
  • These modulations are dynamically altered by task demands, particularly during working memory tasks.
  • Findings underscore the ACC's functional significance in adaptive executive control.