Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methicillin-resistant Staphylococcus epidermidis keratitis treated with vancomycin.

D F Goodman1, J D Gottsch

  • 1Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21205.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1988
PubMed
Summary

Methicillin-resistant Staphylococcus epidermidis (MRSE) causes serious eye infections like keratitis. Topical vancomycin hydrochloride effectively treated two cases of MRSE keratitis, offering a new treatment option for this growing resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune defense at the ocular surface.

Eye (London, England)·2003
Same author

First do no harm: routine use of aminoglycosides in the operating room.

Insight (American Society of Ophthalmic Registered Nurses)·2002
Same author

Microarray analysis of gene expression in human donor corneas.

Archives of ophthalmology (Chicago, Ill. : 1960)·2001
Same author

Spontaneous corneal perforation in a patient with unusual unilateral pellucid marginal degeneration.

Journal of cataract and refractive surgery·2001
Same author

EMAP cytokine expression in developing retinas of normal and retinal degeneration (rd) mutant mice.

Journal of neuroimmunology·2001
Same author

Topical cyclosporin stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers.

Transactions of the American Ophthalmological Society·2001

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Staphylococcus epidermidis is a common cause of bacterial keratitis, particularly in specific regions.
  • Recent shifts in organism sensitivity show increasing resistance to common antibiotics like methicillin, cephalosporins, and aminoglycosides.
  • This resistance is particularly concerning in nosocomially acquired systemic S. epidermidis infections.

Observation:

  • Methicillin-resistant and gentamicin-resistant S. epidermidis has been previously documented in blepharoconjunctivitis and endophthalmitis.
  • Two cases of keratitis caused by methicillin- and gentamicin-resistant S. epidermidis were identified.
  • These specific cases presented a significant clinical challenge due to antibiotic resistance.

Findings:

Related Experiment Videos

  • Both cases of resistant S. epidermidis keratitis were successfully treated with topical vancomycin hydrochloride.
  • Vancomycin hydrochloride demonstrated efficacy against methicillin- and gentamicin-resistant strains.
  • This indicates a potential therapeutic avenue for challenging S. epidermidis eye infections.

    • Implications:

    • Topical vancomycin hydrochloride represents a viable treatment option for severe keratitis caused by multidrug-resistant S. epidermidis.
    • The findings highlight the need for ongoing surveillance of antibiotic resistance patterns in ocular pathogens.
    • This study contributes to the understanding of managing antibiotic-resistant bacterial keratitis.