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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Pars Plana Vitrectomy for Endophthalmitis: Microbiologic Spectrum and Clinical Outcomes

Chang Sup Lee1, Miraj Khan2, Jim Patrie3

  • 1School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

Ocular Immunology and Inflammation
|January 8, 2020
PubMed

Insights

In endophthalmitis patients treated with pars plana vitrectomy (PPV), common bacteria included Streptococcal species and coagulase-negative staphylococcus (CoNS). No antibiotic resistance was found, and culture-negative cases showed better visual outcomes.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Endophthalmitis is a severe intraocular infection often leading to vision loss.
  • Pars plana vitrectomy (PPV) is a common surgical intervention for endophthalmitis.
  • Understanding the microbial spectrum and antibiotic susceptibility is crucial for effective treatment.

Purpose of the Study:

  • To evaluate visual outcomes in endophthalmitis patients undergoing PPV.
  • To identify the common causative organisms and their antibiotic resistance patterns.
  • To compare outcomes between culture-positive and culture-negative endophthalmitis cases.

Main Methods:

  • Retrospective analysis of 32 patients with endophthalmitis who underwent PPV.
  • Microbial analysis of intraocular samples.
  • Statistical comparison of visual acuity (VA) using linear mixed models.

Main Results:

  • Streptococcal species and coagulase-negative staphylococcus (CoNS) were the most frequent pathogens.
  • No resistance to vancomycin or fluoroquinolones was detected.
  • Culture-negative endophthalmitis demonstrated significantly better VA and lower rates of retinal detachment (RD) and hypotony compared to culture-positive cases.

Conclusions:

  • Vancomycin and fluoroquinolones remain effective against common endophthalmitis pathogens.
  • Culture-negative endophthalmitis is associated with more favorable visual prognoses and fewer complications.
  • Non-cataract-related endophthalmitis had a high incidence of secondary retinal detachment.
Keywords:
Endophthalmitisantibiotic resistancepars plana vitrectomy

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