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Calcium transport and energy coupling in diabetic rat liver mitochondria
L Grinblat1, C D Bedetti, A O Stoppani
1Centro de Investigaciones Bioenergéticas, Facultad de Medicina, Universidad de Buenos Aires, Paraguay, Argentina.
Biochemistry International
|August 1, 1988
Abstract:
Liver mitochondria from chronic diabetic rats took up Ca ions at a significantly slower rate than their normal counterparts. The same mitochondria, inhibited with ruthenium red, released Ca ions at a faster rate than normal mitochondria. In good agreement with the decrease of Ca ions uptake, measurement of the inner membrane potential by the safranine method yielded a significantly lower value with diabetic than with normal mitochondria. Respiratory control and P/O ratios were also decreased in diabetic mitochondria.