Simian immunodeficiency virus infection and flow cytometric characterization of Japanese macaque (Macaca fuscata)
Tetsuo Tsukamoto1,2, Katsuki Nakamura3, Seiji Okada1
1Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Journal of Medical Primatology
|January 8, 2020
Abstract:
We characterized Japanese macaque (Macaca fuscata) hematopoietic cells using flow cytometry and identified 28 cross-reactive anti-human antibody clones. Furthermore, productive infection of peripheral T lymphocytes with simian immunodeficiency virus (SIV) in vitro was confirmed by intracellular SIV p27 staining. This study could facilitate using Japanese macaques as models for human hematological and immunological disorders and infectious diseases.
