Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.4K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional connectivity changes in patients with absence epilepsy studied using resting-state functional MRI.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2012
Same author

Quantitative analysis of mitral valve morphology in mitral valve prolapse with real-time 3-dimensional echocardiography: importance of annular saddle shape in the pathogenesis of mitral regurgitation.

Circulation·2012
Same author

Interval cancers in nasopharyngeal carcinoma screening: comparing two screening intervals after a negative initial screening result.

Journal of medical screening·2012
Same author

Two Epstein-Barr virus-related serologic antibody tests in nasopharyngeal carcinoma screening: results from the initial phase of a cluster randomized controlled trial in Southern China.

American journal of epidemiology·2012
Same author

MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Cancer cell·2012
Same author

Extraction and characterization of extracellular polymeric substances in biofilm and sludge via completely autotrophic nitrogen removal over nitrite system.

Applied biochemistry and biotechnology·2012

Related Experiment Video

Updated: Dec 31, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.7K

Technical advances in NK cell-based cellular immunotherapy.

Fang Fang1,2,3,4, Wei Wang2,3,4, Minhua Chen2,3,4

  • 1Department of Oncology of The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

Cancer Biology & Medicine
|January 8, 2020
PubMed
Summary

Natural killer (NK) cell immunotherapy shows promise for cancer treatment. Recent advances in cell sources, genetic engineering, and manufacturing are improving clinical outcomes and future therapeutic strategies.

Keywords:
Natural killer celladoptive cell transfergenetic modificationimmunotherapy

More Related Videos

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.2K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

21.8K

Related Experiment Videos

Last Updated: Dec 31, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.7K
Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.2K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

21.8K

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Natural killer (NK) cells are crucial for innate immunity and possess unique anti-tumor properties.
  • NK cell-based immunotherapy is a rapidly evolving field with significant therapeutic potential for various cancers.

Purpose of the Study:

  • To review recent technical advancements in NK cell-based cellular immunotherapy.
  • To summarize developments in NK cell sources, genetic modification, manufacturing, and clinical applications.
  • To discuss future prospects and challenges in NK cell immunotherapy.

Main Methods:

  • Literature review of recent scientific publications and clinical trial data.
  • Analysis of technical innovations in NK cell expansion and engineering.
  • Synthesis of information on clinical programs and patient outcomes.

Main Results:

  • Significant progress has been made in identifying and optimizing NK cell sources.
  • Genetic modification techniques are enhancing NK cell efficacy and targeting capabilities.
  • Developments in automated and closed manufacturing systems are improving scalability and consistency.

Conclusions:

  • NK cell immunotherapy is a viable and promising approach for cancer treatment.
  • Future directions include off-the-shelf NK cell therapies, improved manufacturing, and overcoming regulatory hurdles.
  • Continued research and technological innovation are essential for realizing the full potential of NK cell immunotherapy.