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Lumbar myelography with iohexol. Adverse effects compared with spinal puncture
1Department of Neurology, Akershus Central Hospital, University of Oslo, Norway.
Acta Radiologica (Stockholm, Sweden : 1987)
|November 1, 1988
Summary
Iohexol is a safe contrast medium for myelography, with side effects similar to spinal puncture. Most adverse events are linked to the procedure, not the contrast agent, suggesting its suitability for outpatients.
Area of Science:
- Radiology
- Neurology
- Pharmacology
Background:
- Iohexol has been the standard contrast medium for myelography since 1983.
- A significant number of myelography procedures have been performed using iohexol.
Purpose of the Study:
- To evaluate the safety and side effect profile of iohexol in myelography.
- To determine if side effects are related to the contrast medium or the spinal puncture procedure.
Main Methods:
- A follow-up study included 331 patients undergoing lumbar myelography.
- Adverse events such as headache, nausea, and vertigo were recorded.
Main Results:
- Headache (26%), nausea (12%), and vertigo (6%) were the most common side effects.
- No severe adverse reactions were observed.
- Minor symptoms like radicular and mental disturbances occurred in a small number of patients.
Conclusions:
- Most side effects associated with myelography are likely due to the spinal puncture procedure.
- Iohexol appears to be a safe contrast medium for myelography, even in outpatient settings.