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Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study
Dana Tzur Bitan1,2, Daniella Berzin3, Arnon Cohen4
1Department of Behavioral Sciences, Ariel University, Ariel, Israel, danatz@ariel.ac.il.
Dermatology (Basel, Switzerland)
|January 8, 2020
Summary
Hidradenitis suppurativa (HS) patients show a higher prevalence of bipolar disorder. This association, however, is not significant after accounting for body mass index, suggesting potential shared risk factors.
Area of Science:
- Dermatology
- Psychiatry
- Epidemiology
Background:
- Psychological comorbidities are common in hidradenitis suppurativa (HS).
- Limited research exists on the link between HS and severe psychiatric disorders like bipolar disorder.
Purpose of the Study:
- To investigate the association between hidradenitis suppurativa (HS) and bipolar disorder.
Main Methods:
- A nationwide, population-based study using the Clalit Health Services database in Israel.
- Included 4,191 HS patients and 20,941 matched controls.
- Multivariate binary logistic regression adjusted for demographic and behavioral factors.
Main Results:
- HS patients had a higher proportion of bipolar disorder (0.7% vs. 0.1%).
- Active smoking was more prevalent in HS patients (53.4% vs. 13.5%).
- HS was independently associated with bipolar disorder (OR 2.12) after adjusting for age, sex, and smoking, but this became nonsignificant after controlling for body mass.
Conclusions:
- Bipolar disorder is associated with HS, though the link may be mediated by other factors.
- Future research should explore cardiometabolic factors.
- Healthcare providers should consider this comorbidity for improved patient management and compliance.
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