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Predictors of poor prognosis in patients with heat stroke

Jae-Kwon Chun1, Sangchun Choi1, Hyuk-Hoon Kim1

  • 1Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.

Clinical and Experimental Emergency Medicine
|January 8, 2020
PubMed

Insights

Increased S100B protein levels predict poor prognosis in heat stroke patients. This biomarker can guide prompt and targeted therapies for heat stroke, improving patient outcomes.

Area of Science:

  • Emergency Medicine
  • Toxicology
  • Biochemistry

Background:

  • Heat stroke (HS) is a severe condition with unknown prognostic predictors.
  • Early identification of patients at risk for poor outcomes is crucial for timely intervention.

Purpose of the Study:

  • To identify independent predictors of poor prognosis in heat stroke patients.
  • To evaluate the S100B protein level as a prognostic biomarker in heat stroke.

Main Methods:

  • Retrospective analysis of health records from 36 heat stroke patients (2008-2017).
  • Univariate and multivariate regression analyses were used to identify prognostic factors.
  • Assessed S100B protein, troponin I, creatinine, ALT, and lactate levels.

Main Results:

  • 27.8% of patients experienced poor prognosis.
  • Elevated S100B protein, troponin I, creatinine, ALT, and lactate were significant in univariate analysis.
  • Increased S100B protein level (OR 177.37) was an independent predictor of poor prognosis (P=0.016).
  • S100B protein cut-off of 0.610 μg/L showed 86% sensitivity and 86% specificity.

Conclusions:

  • Elevated S100B protein on admission is an independent prognostic factor for poor outcomes in heat stroke.
  • S100B protein levels can serve as a target for prompt and specific therapeutic strategies.
Abstract

Keywords:
BiomarkersHeat strokePrognosisS100B protein

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