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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Dec 31, 2025

Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens

Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens

Published on: April 27, 2011

Microarrays in virology: basic concepts and applications for virus detection.

Nicolas Berthet¹, India Leclercq², Tatiana Vallaeys³

¹Institut Pasteur, Épidémiologie et physiopathologie des virus oncogènes, 28, rue du Docteur-Roux, 75015 Paris, France, Centre national de la recherche scientifique, URA 3015, 28, rue du Docteur-Roux, 75015 Paris, France.

Virologie (Montrouge, France)

|January 9, 2020

Summary

This summary is machine-generated.

Molecular methods like quantitative polymerase chain reaction (qPCR) and microarrays revolutionize pathogen detection. This review details microarray technologies and their applications in virology for faster, more specific viral agent identification.

Keywords:

detection and characterization of viral agents electronic microarrays and printed arrays influenza virus in situ synthetized arrays resequencing microarrays suspension bead arrays

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Last Updated: Dec 31, 2025

Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens

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Published on: April 27, 2011

ampliPHOX Colorimetric Detection on a DNA Microarray for Influenza

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Area of Science:

Microbiology
Virology
Molecular Biology

Background:

Molecular methods have significantly advanced pathogen detection and characterization.
Quantitative polymerase chain reaction (qPCR) offers speed, specificity, and cost-effectiveness in viral diagnostics.
Microarrays provide enhanced capabilities for detecting and characterizing a wide range of viruses simultaneously.

Purpose of the Study:

To review the fundamental concepts of various microarray technologies used in virology.
To compare the differences, advantages, and disadvantages of different microarray platforms.
To highlight the applications of microarrays in the detection and characterization of viral agents.

Main Methods:

Overview of microarray technologies, including solid-phase and liquid-phase platforms.
Discussion of probe design, hybridization visualization techniques, and cost considerations.
Analysis of existing microarray-based platforms and their classification.

Main Results:

Microarrays offer a significant increase in detection and characterization capabilities for multiple viruses in a single step.
Different microarray platforms vary in matrix type, probe characteristics, detection methods, and cost.
The review elucidates the distinct features and performance of various microarray systems.

Conclusions:

Microarray technology represents a powerful tool for comprehensive viral diagnostics.
Understanding the nuances of different microarray platforms is crucial for selecting the most appropriate system.
The application of microarrays in virology facilitates efficient and broad-spectrum identification of viral pathogens.