Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

7.4K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
7.4K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

49.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.1K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

4.6K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

Human pathology·2026
Same author

Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models.

Science translational medicine·2026
Same author

Understanding HBV immunopathogenesis to inform future immune-based therapies.

Antiviral research·2026
Same author

CT-based deep learning prediction of complete response in intermediate-stage hepatocellular carcinoma treated with drug-eluting beads transarterial chemoembolization.

BJR artificial intelligence·2026
Same author

Renewed momentum for HCV and HCC research.

Journal of hepatology·2026
Same author

Hepatitis D Virus Pathogenesis: A Sense of Complications.

Viruses·2026
Same journal

[From rhizomania to viral RNAs structure functions].

Virologie (Montrouge, France)·2026
Same journal

[Characteristics of viral gastroenteritis in solid organ transplant patients].

Virologie (Montrouge, France)·2026
Same journal

[ResaFlu/FluResearchNet International symposium,Toulouse, November 26-27, 2025].

Virologie (Montrouge, France)·2026
Same journal

[ViRAE 2025: a landmark inaugural edition for virology at INRAE].

Virologie (Montrouge, France)·2026
Same journal

[13<sup>rd</sup> Cytokines annual meeting, Novembre 2-5 2025, Seattle, USA].

Virologie (Montrouge, France)·2026
Same journal

[Annual report of the French Society for Virology].

Virologie (Montrouge, France)·2026
See all related articles

Related Experiment Video

Updated: Dec 31, 2025

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.6K

Hepatitis C virus internalization.

Laetitia Zona1, Marine Turek1, Thomas F Baumert2

  • 1Inserm U1110, 3, rue Koeberlé, 67000 Strasbourg, France, Université de Strasbourg, 4, rue Blaise-Pascal, 67081 Strasbourg Cedex, France.

Virologie (Montrouge, France)
|January 9, 2020
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) entry into liver cells involves complex viral and cellular interactions. Understanding these Hepatitis C virus mechanisms is crucial for developing new antiviral therapies against this global health threat.

Keywords:
hepatitis C virusinternalizationreceptorssignaling pathways

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.6K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.8K

Related Experiment Videos

Last Updated: Dec 31, 2025

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.6K
A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.6K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.8K

Area of Science:

  • Virology
  • Hepatology
  • Cell Biology

Background:

  • Hepatitis C virus (HCV) infection is a significant global health issue, leading to liver fibrosis, cirrhosis, and cancer.
  • Current treatments for HCV do not guarantee a cure for all patients, and no vaccine is available.
  • Elucidating the HCV life cycle, particularly its entry mechanisms, is vital for developing novel antiviral strategies.

Purpose of the Study:

  • To review recent advancements in understanding the Hepatitis C virus entry process into hepatocytes.
  • To highlight the specific viral and cellular factors involved in HCV attachment and internalization.
  • To identify key signaling pathways implicated in HCV entry.

Main Methods:

  • This review synthesizes current research findings on HCV entry.
  • It analyzes the roles of various cellular receptors on hepatocytes.
  • It examines the contribution of intracellular proteins to viral internalization.

Main Results:

  • Hepatitis C virus entry is a multi-step process involving initial attachment to host cell surface receptors.
  • Numerous viral and cellular factors mediate the complex internalization and genome release into the cytoplasm.
  • Specific cell surface molecules and intracellular proteins are critical for successful viral entry.

Conclusions:

  • A comprehensive understanding of HCV entry mechanisms is essential for antiviral drug development.
  • Targeting the intricate interplay of viral and cellular factors during entry presents a promising therapeutic avenue.
  • Further research into HCV entry pathways will accelerate the development of more effective treatments and potential preventative strategies.