Related Experiment Video

Updated: Dec 31, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

20.0K

Assessment of subclinical left ventricular dysfunction with speckle-tracking echocardiography in hyperthyroid and

Irfan Veysel Duzen1, Suzan Tabur2, Sadettin Ozturk2

  • 1Department of Cardiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

Acta Cardiologica
|January 9, 2020
PubMed

Insights

Graves' disease is linked to poorer heart function and higher tissue inhibitor of metalloproteinase-1 (TIMP-1) levels, regardless of thyroid hormone status. This indicates a potential cardiovascular impact even in euthyroid patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Graves' disease significantly impacts cardiovascular function.
  • Speckle-tracking echocardiography detects subclinical left ventricular dysfunction better than conventional methods.
  • Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular matrix regulator.

Purpose of the Study:

  • To compare longitudinal global strain (GLS) and TIMP-1 levels in hyperthyroid Graves' patients, euthyroid Graves' patients, and healthy controls.
  • To investigate the relationship between GLS and TIMP-1 in Graves' disease.
  • To determine if cardiovascular changes in Graves' disease are thyroid hormone-dependent.

Main Methods:

  • Enrolled 40 hyperthyroid Graves' patients, 40 euthyroid Graves' patients, and 40 healthy controls.
  • Utilized conventional and speckle-tracking echocardiography for GLS assessment.
  • Measured serum TIMP-1 concentrations in all participants.

Main Results:

  • Hyperthyroid and euthyroid Graves' patients exhibited lower GLS compared to controls.
  • Serum TIMP-1 levels were elevated in both hyperthyroid and euthyroid Graves' patients versus controls.
  • TIMP-1 levels negatively correlated with GLS, independent of thyroid hormone levels.

Conclusions:

  • Graves' disease is associated with impaired GLS and elevated TIMP-1.
  • These cardiovascular changes and elevated TIMP-1 persist even when thyroid hormone levels are normalized.
  • The findings suggest a potential intrinsic cardiovascular impact of Graves' disease beyond hyperthyroidism.
Abstract

Keywords:
Graves’TIMP-1strainthyroid

More Related Videos

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

28.4K
Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.3K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
386
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
168
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
162
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
263
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
327
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
204