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Updated: Dec 31, 2025
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Squamous Cell Carcinoma Associated with Cosmetic Use of Bleaching Agents: About a Case in Ivory Coast
Koffi Kouamé Pacôme Gbandama1, Almamy Diabaté2, Kouamé Alexandre Kouassi1
1Department of Dermatology and Venereology, University Hospital of Treichville, University Félix Houphouët-Boigny of Abidjan, Abidjan, Ivory Coast.
Abstract:
Voluntary skin depigmentation is defined as a set of procedures for obtaining skin clarification for cosmetic purposes. Skin cancers are possible complications, but rarely reported. We describe a case observed in Ivory Coast. A 52-year-old Ivorian woman consulted the Dermatology Department of the University Hospital of Treichville, Abidjan for an ulceration of the middle third of the right clavicle evolving for 10 months. A diagnosis of squamous cell carcinoma (SCC) was confirmed by histological examination of the tumour biopsy. Retroviral serology (HIV) was negative. An excision of the tumour was performed. The postoperative consequences were simple. We report a case of SCC following long-term use of depigmenting cosmetic products in a female phototype VI. SCC is the most common skin cancer among black Africans. It is secondary to precancerous lesions or takes place on a damaged skin. Concerning our patient, the onset of this carcinoma could be associated with the carcinogenic effect of hydroquinone and topical corticoids used for a long time. In addition, no precancerous lesion or preexisting condition were found. The chronic evolution without healing was in favour of a neoplastic origin achieved through the analysis of the biopsy sample.
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