Related Experiment Video
Updated: Dec 31, 2025
06:03
Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
8.3K
Hydrophobic Organic Matter Promotes Coxsackievirus B5 Stabilization and Protection from Heat
P Waldman1, F S Lucas1, G Varrault1
1Laboratoire Eau Environnement Et Systèmes Urbains (LEESU, UMR MA 102), Faculté des Sciences Et Technologie, Université Paris-Est, 61 Avenue du Général de Gaulle, 94000, Créteil, France.
Food and Environmental Virology
|January 9, 2020
Summary
Environmental organic matter in freshwater protects viruses from heat. Hydrophobic compounds are particularly effective, suggesting local conditions significantly influence virus persistence in rivers used for drinking water.
Area of Science:
- Environmental microbiology
- Water quality research
- Virology
Background:
- Urban rivers face viral contamination, impacting drinking water safety.
- The role of environmental organic matter in virus survival is understudied.
- Understanding factors affecting virus persistence is crucial for water treatment.
Purpose of the Study:
- To investigate the protective effects of environmental organic matter on coxsackievirus B5 heat resistance.
- To determine if particulate or dissolved organic matter fractions influence virus stability.
- To assess the role of hydrophobic compounds in virus protection.
Main Methods:
- Freshwater was fractionated to isolate particulate and dissolved organic matter.
- Coxsackievirus B5 was exposed to different organic matter fractions and heat.
- Virus resistance to heat inactivation was measured.
Main Results:
- Environmental waters contain compounds protecting viruses from heat inactivation.
- Both particulate and dissolved organic matter fractions demonstrated protective capabilities.
- Hydrophobic compounds were found to be particularly effective in promoting virus resistance.
Conclusions:
- Environmental organic matter, particularly hydrophobic compounds, significantly impacts virus persistence.
- Local water conditions can enhance virus survival against heat stress.
- Further research is needed to understand the full implications for drinking water safety.
Related Concept Videos
02:42Aqueous Solutions and Heats of Hydration
17.2K
Water and other polar molecules are attracted to ions. The electrostatic attraction between an ion and a molecule with a dipole is called an ion-dipole attraction. These attractions play an important role in the dissolution of ionic compounds in water.
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
17.2K
00:59COP Coated Vesicles
16.7K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
16.7K
01:29Diversity of Archaea IV
353
Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
353
01:18Surface Membrane Barriers
2.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.5K
01:27Chemical Agents for Microbial Control
667
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
667
01:23Membrane Fluidity
171.6K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
171.6K