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Updated: Dec 31, 2025

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Endocytosis, cadherins and tissue dynamics
Hiroko Katsuno-Kambe1, Alpha S Yap1
1Department of Cell and Developmental Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Abstract:
By happy chance, the founding of Traffic in 1999 coincided with a clutch of reports that documented the endocytosis and recycling of classical cadherin adhesion receptors. This stimulated a concerted effort to elucidate the molecular regulation of cadherin endocytosis and to identify its functional implications. In particular, endocytosis provided new perspectives to understand how cadherins are modulated during tissue morphogenesis. In this short article, we consider some of what we have learnt about this problem and identify open questions for future research.
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