Intestinal absorption of oyster shell electrolysate

Area of Science:

• Biochemistry
• Nutritional Science
• Materials Science

Background:

• Calcium carbonate is a common calcium supplement, but its absorption can be limited.
• Oyster shells are a natural source of calcium, but their bioavailability needs investigation.
• Electrolysis may alter the crystalline structure and bioavailability of oyster shell calcium.

Purpose of the Study:

• To investigate the crystalline structure of oyster shell electrolysate.
• To compare the intestinal absorption and efficacy of oyster shell electrolysate with calcium carbonate.
• To evaluate oyster shell electrolysate in animal models and human patients with calcium absorption issues.

Main Methods:

• Oyster shell powder was electrolyzed using high voltage electric current.
• The crystalline structure of the electrolysate was analyzed.
• Oral administration of oyster shell electrolysate and calcium carbonate was performed in vitamin D-deficient rats.
• Clinical studies were conducted in patients with postoperative hypoparathyroidism and secondary hyperparathyroidism.

Main Results:

• Electrolysis resulted in a distinct crystalline shape for oyster shell electrolysate compared to CaO or CaCO3.
• Vitamin D-deficient rats showed higher serum calcium levels with oyster shell electrolysate than with calcium carbonate.
• In hypoparathyroid patients, oyster shell electrolysate was more effective than calcium carbonate in raising serum calcium without vitamin D supplementation.
• Oyster shell electrolysate more effectively suppressed parathyroid hormone in renal failure patients compared to calcium carbonate.

Conclusions:

• Oyster shell electrolysate exhibits superior intestinal calcium absorption compared to calcium carbonate.
• This enhanced absorption is particularly evident in conditions of vitamin D deficiency or impaired intestinal function.
• Oyster shell electrolysate represents a promising alternative calcium supplement for improving calcium homeostasis.