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Related Experiment Video

Updated: Dec 31, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

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Published on: May 1, 2015

Genetic predisposition for multiple myeloma.

Maroulio Pertesi¹, Molly Went², Markus Hansson¹

¹Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, 221 84, Lund, Sweden.

|January 9, 2020

Summary

Multiple myeloma (MM) is a common blood cancer with familial links. Recent genetic studies reveal inherited predispositions and identify risk genes, advancing our understanding of its development.

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Published on: December 13, 2018

Area of Science:

Hematology
Genetics
Cancer Research

Background:

Multiple myeloma (MM) is the second most prevalent blood cancer.
Family studies suggest a genetic component in a subset of MM cases.
Recent research is providing direct evidence for inherited genetic predisposition to MM.

Purpose of the Study:

To review recent findings in the field of multiple myeloma genetic predisposition.
To highlight current knowledge gaps and suggest future research directions.

Main Methods:

Genome-wide association studies (GWAS) to identify common risk alleles.
Sequencing studies of familial cases and kindreds to find high-effect risk genes.
Functional studies to understand how identified risk alleles contribute to MM development.

Main Results:

Identification of common risk alleles at 24 independent loci through GWAS.
Discovery of candidate genes with potentially strong effects on MM risk in familial cases.
Emerging insights into the functional mechanisms by which genetic variants promote MM.

Conclusions:

Genetic predisposition plays a significant role in a subset of multiple myeloma cases.
Ongoing research is elucidating the genetic architecture and biological pathways underlying MM risk.
Future studies are needed to fully understand the inherited basis of MM and translate findings into clinical applications.