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Updated: Dec 31, 2025
09:12
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
10.4K
Incidence and Outcomes Associated With Clostridium difficile Infections: A Systematic Review and Meta-analysis
Alexandre R Marra1,2,3, Eli N Perencevich1,3, Richard E Nelson4,5
1Carver College of Medicine, Department of Internal Medicine, University of Iowa, Iowa City.
JAMA Network Open
|January 9, 2020
Summary
Clostridium difficile infection (CDI) affects 8.3 per 10,000 patient-days in the US. CDI significantly increases hospital length of stay (LOS), ranging from 3 to 21.6 days, highlighting a substantial healthcare burden.
Area of Science:
- Infectious Diseases
- Epidemiology
- Health Services Research
Background:
- Clostridium difficile infection (CDI) poses a significant challenge to healthcare systems.
- Understanding the incidence and outcomes of CDI is crucial for developing effective interventions.
Purpose of the Study:
- To systematically review and meta-analyze the incidence of CDI in the United States.
- To quantify the association between CDI and hospital length of stay (LOS).
Main Methods:
- A systematic literature search was conducted across major databases for US-based studies from 2000-2019.
- Data from multicenter studies on CDI incidence and propensity score-matched studies on LOS were pooled.
- Random-effects models were employed for meta-analysis, with heterogeneity assessed using I2 statistics.
Main Results:
- The pooled incidence of hospital-onset CDI was 8.3 cases per 10,000 patient-days.
- CDI was associated with an increased mean LOS, ranging from 3.0 to 21.6 days in propensity score-matched studies.
- Significant heterogeneity was observed across studies.
Conclusions:
- Pooled data indicate a substantial healthcare burden associated with CDI in the United States.
- Further high-quality research is recommended to refine estimates and guide prevention and treatment strategies.
- These findings underscore the importance of continued investment in CDI control measures.
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