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Oxybutynin: is it safe?

R J Baigrie1, J P Kelleher, D P Fawcett

  • 1Department of Urology, Battle Hospital, Reading.

British Journal of Urology
|October 1, 1988
PubMed
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Oxybutynin is frequently prescribed in the UK. While 57% of patients benefited, 76% experienced side effects, though none were severe or permanent, highlighting the need for understanding its safety profile.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Patient Safety

Background:

  • Oxybutynin has been available in the UK for over five years via named patient prescriptions.
  • Limited literature exists regarding the side effect profile of oxybutynin.
  • Comprehensive understanding of oxybutynin's side effects is crucial due to its widespread use.

Purpose of the Study:

  • To investigate the efficacy and side effect profile of oxybutynin in a real-world clinical setting.
  • To assess the safety and tolerability of oxybutynin in patients receiving named patient prescriptions.

Main Methods:

  • A retrospective review of 192 consecutive patients prescribed oxybutynin in a district general hospital.
  • Data collection focused on patient-reported benefits and observed side effects.

Related Experiment Videos

  • Comparison of efficacy and side effects between oxybutynin from two major suppliers.

    • Main Results:

    • Oxybutynin demonstrated benefit in 57% of patients.
    • A high incidence of side effects (76%) was observed.
    • No reported side effects were dangerous or irreversible.
    • No significant differences in efficacy or side effects were noted between the two main suppliers.

    Conclusions:

    • Oxybutynin is effective for many patients but commonly associated with side effects.
    • The observed side effects are generally mild and transient.
    • The study underscores the importance of monitoring patients for side effects, even when the drug is prescribed on a named patient basis.
    • Further discussion on the medicolegal aspects of named patient prescriptions is warranted.