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Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
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Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites
Nicolas Debons1, Dounia Dems, Christophe Hélary
1Sorbonne Université, CNRS, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Paris, F-75005, France. Carole.aime@ens.fr.
Biomaterials Science
|January 10, 2020
Abstract:
Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
