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Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...

Reduction of Alkenes: Catalytic Hydrogenation

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Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.

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Updated: Dec 31, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

Recent Advances in Continuous-Flow Enantioselective Catalysis.

Tao Yu¹, Zhengwei Ding¹, Wenzheng Nie²

¹Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|January 10, 2020

Summary

Continuous-flow manufacturing and enantioselective catalysis are advancing fine chemical and pharmaceutical production. These methods offer improved efficiency, safety, and selectivity compared to traditional batch processes.

Keywords:

biocatalysts enantioselective catalysts flow chemistry heterogeneous catalysts homogeneous catalysts

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Last Updated: Dec 31, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

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Published on: January 4, 2018

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

Area of Science:

Chemical Engineering
Organic Chemistry
Green Chemistry

Background:

Growing demand for efficient, safe, and green production in the fine chemical and pharmaceutical industries.
Need for advanced manufacturing techniques, particularly for chiral chemical synthesis.
Emergence of continuous-flow manufacturing as a promising alternative to batch processing.

Purpose of the Study:

To review recent advancements in continuous-flow enantioselective catalysis.
To summarize key strategies, methods, and technologies developed in the last six years.
To identify remaining challenges in the field.

Main Methods:

Review of literature on continuous-flow enantioselective catalytic processes.
Analysis of homogeneous, heterogeneous, and enzymatic catalytic systems in flow.
Comparison of flow processes with conventional batch methods.

Main Results:

Continuous-flow enantioselective processes demonstrate significant advantages over batch modes.
Key benefits include shortened reaction times, reduced catalyst loadings, and enhanced selectivities.
Progress has been made in various catalytic systems, including homogeneous, heterogeneous, and enzymatic approaches.

Conclusions:

Continuous-flow enantioselective catalysis is a rapidly advancing field with substantial potential.
These methods offer superior efficiency, safety, and sustainability for chiral chemical production.
Further research is needed to address existing challenges and optimize flow processes.