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Updated: Dec 31, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Recent Advances in Continuous-Flow Enantioselective Catalysis
Tao Yu1, Zhengwei Ding1, Wenzheng Nie2
1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Abstract:
The increased demand for more efficient, safe, and green production in fine chemical and pharmaceutical industry calls for the development of continuous-flow manufacturing, and for chiral chemicals in particular, enantioselective catalytic processes. In recent years, this emerging direction has received considerable attention and has seen rapid progress. In most cases, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode, such as shortened reaction times, lower catalysts loadings, and higher selectivities in addition to the normal merits of non-enantioselective flow operations. In this Minireview, the advancements, key strategies, methods, and technologies developed the last six years as well as remaining challenges are summarized.
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