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Left ventricular non-compaction in patients with single ventricle heart disease

Preeti Choudhary1,2, Wendy Strugnell3, Rajesh Puranik1,2

  • 1Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.

Cardiology in the Young
|January 10, 2020
PubMed

Insights

Left ventricular non-compaction is common in single ventricle heart disease, affecting 37% of patients. This condition is linked to larger left ventricular volumes and reduced systolic function.

Area of Science:

  • Cardiology
  • Congenital Heart Disease
  • Cardiac Imaging

Background:

  • Left ventricular non-compaction (LVNC) is a myocardial abnormality associated with heart failure, thromboembolism, and arrhythmia.
  • Single ventricle heart disease (SVHD) presents unique challenges in cardiac morphology and function.

Purpose of the Study:

  • To determine the prevalence of LVNC in patients with SVHD.
  • To evaluate the impact of LVNC on ventricular function in this population.

Main Methods:

  • Retrospective review of cardiac MRI data from 65 patients with SVHD.
  • LVNC defined by a non-compacted:compacted myocardial thickness ratio >2.3:1.
  • Correlation of LVNC distribution with ventricular volumes and function.

Main Results:

  • LVNC was present in 37% of patients (24/65), predominantly in apical segments.
  • Patients with LVNC exhibited significantly higher end-diastolic and end-systolic left ventricular volumes.
  • Lower left ventricular ejection fraction was observed in patients with LVNC.

Conclusions:

  • LVNC is frequently identified in patients with left ventricle-type univentricular hearts.
  • LVNC presence is associated with increased indexed end-diastolic volumes and impaired systolic function in SVHD patients.
Abstract

Keywords:
Fontanadult congenital heart diseasecardiac MRIheart failurenon-compactionuniventricular physiology

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