Related Experiment Video

Updated: Aug 11, 2026

Determining the Phagocytic Activity of Clinical Antibody Samples
09:05

Determining the Phagocytic Activity of Clinical Antibody Samples

Published on: November 30, 2011

24.0K

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in

Helena Bergsten1, Martin Bruun Madsen2, Francois Bergey3

  • 1Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Stockholm, Sweden.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|January 10, 2020
PubMed

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.

Keywords:
Streptococcus pyogenesintravenous immunoglobulin Gnecrotizing fasciitisnecrotizing soft tissue infectionssuperantigens

More Related Videos

Measuring Influenza Neutralizing Antibody Responses to AH3N2 Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells12:09

Measuring Influenza Neutralizing Antibody Responses to AH3N2 Viruses in Human Sera by Microneutralization Assays Using MDCK-SIAT1 Cells

Published on: November 22, 2017

18.6K
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.4K

Related Concept Videos

Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...