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Related Experiment Video

Updated: Dec 31, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Rapid progressive lung cancers harbouring multiple clonal driver mutations with big bang evolution model.

Kei Kunimasa1, Yosuke Hirotsu2, Harumi Nakamura3

  • 1Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan; Genome Analysis Center, Yamanashi Central Hospital, Yamanashi, Japan.

Cancer Genetics
|January 10, 2020
PubMed
Summary

Advanced lung cancer patients with multiple driver mutations may experience rapid, aggressive progression. This rapid tumor evolution, termed a "big bang" model, can lead to widespread, hard-to-detect metastases and a poor prognosis.

Keywords:
Cancer evolution modelMultiple clonal driver mutationNext generation sequence

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Area of Science:

  • Oncology
  • Genomics
  • Cancer Evolution

Background:

  • Next-generation sequencing (NGS) aids in understanding tumor evolution and patient prognosis.
  • Advanced lung cancer often presents complex evolutionary patterns.

Observation:

  • Two advanced lung cancer patients with rapidly deteriorating clinical courses were studied.
  • Targeted sequencing of multiple metastases and PyClone analysis were performed.

Findings:

  • Both patients exhibited multiple clonal driver mutations (e.g., KRAS, TP53, PTEN) across all metastatic lesions.
  • The tumor progression followed a punctuated,
  • big bang
  • evolutionary model.

Implications:

  • Lung cancer patients with multiple clonal driver mutations require close clinical monitoring.
  • Rapid tumor evolution can result in rapid, systemic metastasis development.
  • Understanding tumor evolution aids in predicting patient prognosis.