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QT Wave Dispersion in Patients With Major Depressive Disorder.

Sevda Korkmaz1,2, Dilek Bakiş Aksoy2, Mustafa Çakar2

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This summary is machine-generated.

Patients with depression exhibit higher corrected QT dispersion (QTcd) compared to healthy individuals. This increased QTcd positively correlates with depression and anxiety symptom severity.

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Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Electrophysiology

Background:

  • QT wave dispersion (QTd) research in depressive disorder is limited.
  • Understanding cardiac repolarization abnormalities in depression is crucial for patient management.

Purpose of the Study:

  • To compare QTd between patients with major depressive disorder and healthy controls.
  • To investigate the correlation between QTd and depression/anxiety scores.

Main Methods:

  • Forty patients with major depressive disorder (DSM-5) and 40 healthy controls were recruited.
  • Electrocardiograms were used to calculate corrected QT dispersion (QTcd).
  • Beck Depression Inventory and Beck Anxiety Inventory assessed symptom severity.

Main Results:

  • Depressed patients showed significantly higher QTcmax and QTcd values than controls.
  • Higher Beck Depression Inventory and Beck Anxiety Inventory scores were observed in the patient group.
  • A positive correlation was found between QTcd, QTcmax, and anxiety/depression scores.

Conclusions:

  • Depressed patients have elevated QTcd compared to healthy individuals.
  • Increased QTcd in depression is associated with higher depression and anxiety symptom severity.