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The pleura and the endocrine system
Claudio Sorino1, Stefano Negri2, Antonio Spanevello3
1Division of Pulmonology, Sant'Anna Hospital, Como, Italy; University of Insubria, Varese, Italy.
European Journal of Internal Medicine
|January 11, 2020
Summary
The endocrine system and pleura interact, with hormones impacting pleural conditions like hypothyroidism and endometriosis. Some pleural tumors also cause hormonal imbalances, affecting patient health.
Area of Science:
- Endocrinology
- Pulmonology
- Oncology
Background:
- The pleura and endocrine system have interconnected functions.
- Hormone levels can differ in pleural fluid compared to blood, though clinical significance is unclear.
- Hormonal dysregulation can manifest as pleural pathologies.
Purpose of the Study:
- To explore the relationship between endocrine disorders and pleural diseases.
- To highlight how hormonal changes contribute to pleural effusion, endometriosis, and cancer.
- To discuss the role of endocrine therapy in managing hormone-sensitive pleural conditions.
Main Methods:
- Review of existing literature on endocrine-related pleural diseases.
- Analysis of hormonal influences in conditions such as hypothyroidism, thoracic endometriosis, and hormone-sensitive cancers.
- Examination of endocrine-secreting pleural tumors.
Main Results:
- Hypothyroidism can cause pleural effusion via capillary permeability changes.
- Thoracic endometriosis leads to catamenial pneumothorax/hemothorax, treatable with hormone therapy.
- Malignant pleural effusions (breast, thyroid cancer, LAM) and solitary fibrous tumors of the pleura (SFPT) demonstrate hormone sensitivity or secretion, impacting systemic health.
Conclusions:
- Hormonal factors play a significant role in various pleural diseases.
- Endocrine assessment and treatment are crucial for managing specific pleural conditions.
- Further research is needed to fully elucidate the clinical implications of hormone-pleura interactions.
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