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Updated: Dec 31, 2025

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Published on: June 10, 2021
Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction
Mohammad Reza Asghariganjeh1,2, Ali Asghar Mohammadi3, Elham Tahanpesar2
1Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran.
Abstract:
Electro-synthesis through a one-pot three-component condensation of corresponding aldehydes, Meldrum's acid, and 2-(nitromethylene)imidazolidine resulted in a series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing an electronegative pharmacophore (=CNO2). The process was carried out in propanol medium with sodium bromide presented as electrolyte, inside an undivided cell with good to excellent yields. As a powerful entry into fused polycyclic structures related to bioactive heterocycles, this green protocol shows great potential.
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