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Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good
Laetitia Voilquin1,2,3,4, Thomas Di Mattia1,2,3,4, Fabien Alpy1,2,3,4
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Abstract:
Enteroviruses, members of the Picornaviridae family, are non-enveloped and single-stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane-bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriched in phosphatidylinositol 4-phosphate (PI4P) produced by the host lipid kinase PI4KB. In this issue of EMBO Reports, McPhail et al [1] characterize a complex, formed by PI4KB and the c10orf76 protein, which is involved in PI4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication.
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