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An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
Nagaraja SreeHarsha1,2, Katharigatta N Venugopala1,3, Anroop B Nair1
1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Drug Design, Development and Therapy
|January 11, 2020
Summary
This study demonstrates that salbutamol-loaded microspheres offer an effective lung-targeted drug delivery system for asthma treatment, improving drug concentration and efficacy compared to conventional methods.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Respiratory Medicine
Background:
- Chronic diseases, including asthma, are leading causes of death in developing nations.
- Conventional asthma treatments often result in ineffective drug delivery to the lungs and undesirable side effects.
- Microspheres present a promising alternative for targeted drug delivery in respiratory conditions.
Purpose of the Study:
- To develop and optimize a salbutamol-loaded poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) microsphere formulation for enhanced lung delivery.
- To evaluate the efficacy and safety of this novel microsphere-based drug delivery system for asthma treatment.
Main Methods:
- Salbutamol-loaded PLGA-PEG microspheres were prepared using a nanospray drier.
- Face-centered central composite design (CCD) was employed to optimize the spray-drying process parameters.
- In vitro drug release, particle size analysis, in vivo efficacy studies in rabbits, stability testing, and cytotoxicity assays on A549 cell lines were conducted.
Main Results:
- The optimized microsphere formulation achieved a drug content of 72%±0.8% and a product yield of 86%±0.4%.
- In vitro drug release reached 91.1% over 12 hours. The particle size was determined to be 8.24 µm.
- In vivo studies showed significantly higher drug concentration and targeting efficacy in the lungs with the microsphere formulation (1,410.1±10.11 µg/g at 15 min) compared to conventional methods (92±0.56 µg/g at 10 min).
- The microspheres demonstrated good stability and a favorable safety profile.
Conclusions:
- Salbutamol-loaded PLGA-PEG microspheres represent a viable and effective alternative for lung-targeted asthma therapy.
- This novel drug delivery system enhances drug concentration in the lungs, potentially improving treatment outcomes for asthma patients.
- The developed microspheres offer a safe and stable option for public health interventions in managing chronic respiratory diseases.
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