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Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

Mao-Qiang Man1,2, Peter M Elias2

  • 1Dermatology Hospital of Southern Medical University, Guangzhou 510091, People's Republic of China.

Clinical Interventions in Aging
|January 11, 2020
PubMed
Summary
This summary is machine-generated.

Aging skin inflammation, or inflammaging, is linked to chronic diseases. Improving skin barrier function may reduce inflammation and prevent age-related disorders.

Keywords:
agingepidermisinflammaginginflammationsystemic disorders

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Area of Science:

  • Gerontology
  • Dermatology
  • Immunology

Background:

  • Aging is associated with chronic, low-grade inflammation (inflammaging).
  • Inflammaging is linked to age-related diseases like type 2 diabetes, cardiovascular disease, Alzheimer's, and obesity.
  • Inflammatory skin conditions are risk factors for some age-related systemic disorders.

Purpose of the Study:

  • To investigate the skin's role as a contributor to inflammaging.
  • To explore epidermal dysfunction as a driver of systemic inflammation in aging.
  • To assess the potential of correcting epidermal dysfunction to mitigate age-related inflammation.

Main Methods:

  • Review of epidemiological studies on inflammatory dermatoses and systemic disorders.
  • Analysis of recent research on aged skin and its inflammatory cytokine production.
  • Examination of studies using topical emollients to improve epidermal function and reduce inflammation.

Main Results:

  • Epidermal dysfunction in aged skin contributes to cutaneous inflammation and increased proinflammatory cytokines.
  • The skin may be a significant contributor to systemic inflammaging.
  • Improvements in epidermal function with topical treatments reduced proinflammatory cytokines in aged subjects.

Conclusions:

  • Correction of epidermal dysfunction presents a novel therapeutic strategy.
  • Targeting skin barrier repair could help prevent and manage inflammation-associated chronic disorders in aging.
  • The skin's role in inflammaging highlights the importance of dermatological health in systemic aging processes.