Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription01:10

Transcription

158.7K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
158.7K
Adaptations that Reduce Water Loss01:57

Adaptations that Reduce Water Loss

28.8K
Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
28.8K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Regulation of Transpiration by Stomata02:04

Regulation of Transpiration by Stomata

32.2K
During photosynthesis, plants acquire the necessary carbon dioxide and release the produced oxygen back into the atmosphere. Openings in the epidermis of plant leaves is the site of this exchange of gasses. A single opening is called a stoma—derived from the Greek word for “mouth.” Stomata open and close in response to a variety of environmental cues.
32.2K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.6K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibronectin-Based Skin Care Regimens for Skin Recovery After Intense Pulsed Light Therapy: A Split-Face Study.

Clinical, cosmetic and investigational dermatology·2026
Same author

Comprehensive Evaluation of a Cream With Advanced Soothing Complex for Skin Recovery Following Intense Pulsed Light Therapy.

Journal of cosmetic dermatology·2026
Same author

Skin Care Supports Overall Well-Being.

Clinical, cosmetic and investigational dermatology·2025
Same author

The role of psychological stress in the pathogenesis of psoriasis.

Frontiers in medicine·2025
Same author

Comparative analysis of epidermal gene expression in mice exposed to deionized water and groundwater.

Ecotoxicology and environmental safety·2025
Same author

Stratum corneum hydration levels are negatively correlated with HbA1c levels in the elderly Chinese.

Journal of diabetes·2024

Related Experiment Video

Updated: Mar 27, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

12.0K

Low Humidity Alters Epidermal Gene Expression in vivo.

Si Wen1, Xiaohua Wang2, Li Ye1

  • 1Evaluation Center for Skin Care Product Efficacy, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 510091, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|March 26, 2026
PubMed
Summary

Low humidity significantly alters skin gene expression, impacting inflammatory and signaling pathways. Topical emollient application helps regulate these changes, suggesting its benefit for managing skin in dry environments.

Keywords:
RNA sequencingcytokinesemollientenvironmentepidermishumidity

More Related Videos

Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring
05:22

Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring

Published on: January 20, 2023

2.3K
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

13.5K

Related Experiment Videos

Last Updated: Mar 27, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

12.0K
Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring
05:22

Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring

Published on: January 20, 2023

2.3K
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

13.5K

Area of Science:

  • Dermatology and Environmental Science
  • Molecular Biology and Genomics

Background:

  • Environmental factors like humidity influence skin barrier function.
  • The specific effects of low humidity on epidermal gene expression remain largely unknown.

Purpose of the Study:

  • To investigate the impact of low humidity on mouse epidermal gene expression.
  • To determine if a topical emollient can mitigate these effects.

Main Methods:

  • RNA sequencing (RNAseq) was used to analyze epidermal gene expression in mice.
  • Mice were exposed to low humidity (15%) with or without emollient treatment.
  • Control group maintained in normal humidity (55±5%).

Main Results:

  • Low humidity altered gene expression, downregulating 159 and upregulating 105 genes.
  • Emollient treatment modulated gene expression, upregulating 195 and downregulating 280 genes.
  • Low humidity affected cytokine and signaling pathways, while emollient influenced fatty acid metabolism and reduced inflammation-associated genes.

Conclusions:

  • Low humidity significantly alters epidermal gene expression.
  • Topical emollients can regulate gene expression in response to low humidity.
  • Findings support the use of emollients for skin health in dry environments and managing dry skin conditions.