Related Experiment Video
Updated: Dec 31, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
Hyperuricemia and Hypertension: Links and Risks
Douglas J Stewart1, Valerie Langlois1,2, Damien Noone1,2
1Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Abstract:
Hyperuricemia has long been recognized to be associated with increased cardiovascular risk, including risk of developing hypertension. Epidemiological findings suggest that the link with hypertension is stronger in children and adolescents. Uric acid acts as a strong antioxidant compound in the extracellular environment but has pro-inflammatory effects within the intracellular setting. A chronic phase of microvascular injury is known to occur after prolonged periods of hyperuricemia. This is proposed to contribute to afferent arteriolopathy and elevation of blood pressure that may become unresponsive to uric acid-lowering therapies over time. Studies have struggled to infer direct causality of hyperuricemia due to a vast number of confounders including body mass index. The aim of this review is to present the available data and highlight the need for large scale prospective randomized controlled trials in this area. At present, there is limited evidence to support a role for uric acid-lowering therapies in helping mitigate the risk of hypertension.
More Related Videos
10:02Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
Published on: October 3, 2020
07:52A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Hypertension II: Pathophysiology
Antihypertensive Drugs: Action of Diuretics
Hypertension I: Introduction
Hypertension III: Clinical Manifestations and Diagnostic Studies
Urinary Tract Calculi IV: Nutrition Therapy and Prevention